Neuroblastoma an Aggressive Childhood Tumor
Children are most affected with a very aggressive brain tumor that bears the name of neuroblastoma.
This tumor would be associated with a genetic trait through a variation in DNA copy number according to a study by Children’s Hospital of Philadelphia and the Pennsylvania School of Medicine published in the journal Nature.
This tumor, usually fatal to the victim, could be part of a chain of variations in DNA copy number (CNV). Such changes are present between the nucleotide polymorphisms (SNPs), which features the one hand (in some cases) is a nature susceptible to cancer.
The study was led by John Maris, and it involved an analysis of genome-wide association in patients with neuroblastoma. Among the conclusions reached VNC was discovered on chromosome 1 that could be associated with the disease.
The research team has determined that this genome is usually expressed in fetal brain tissue and would be involved in the initial stages of tumor development.
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Tags: Children, neuroblastoma, tumor